Recombinant Human ITPR2 Protein

Tag: C-His. Modification: unmodified. Start Site: Phe2421. End Site: Asp2510. Coverage: 0.03. Isoelectric Point: 5.5. Core Sequence: FTMEVDRLKN RTPVTGSHQV PTMTLTTMME ACAKENCSPT IPASNTADEE YEDGIERTCD TLLMCIVTVL NQGLRNGGGV GDVLRRPSKD. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 91%, Rat - 86%, Pig - 89%, Cynomolgus monkey - 100%, Protein Function: Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states, a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity) [The Uniprot Consortium]