Recombinant Human IRAG1 Protein

Tag: C-His. Modification: unmodified. Start Site: Gln531. End Site: Lys650. Coverage: 0.14. Isoelectric Point: 7. Core Sequence: QLSLAFRNDS YTLESRINQA ERERNLTEEN TEKELENFKA SITSSASLWH HCEHRETYQK LLEDIAVLHR LAARLSSRAE VVGAVRQEKR MSKATEVMMQ YVENLKRTYE KDHAELMEFK. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 98%, Pig - 99%, Cynomolgus monkey - 99%, Protein Function: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release, its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Also mediates NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation (PubMed:14729908). Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity) [The Uniprot Consortium]