Recombinant Human INIP Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Met1. End Site: Glu104. Coverage: 1. Isoelectric Point: 6.5. Core Sequence: MAANSSGQGF QNKNRVAILA ELDKEKRKLL MQNQSSTNHP GASIALSRPS LNKDFRDHAE QQHIAAQQKA ALQHAHAHSS GYFITQDSAF GNLILPVLPR LDPE. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 96%, Pig - 99%, Cynomolgus monkey - 100%, Protein Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways [The Uniprot Consortium]