Recombinant Human HCN2 Protein

Tag: C-His. Modification: unmodified. Start Site: Pro761. End Site: Ser880. Coverage: 0.15. Isoelectric Point: 12.5. Core Sequence: PPPGPAPAAA SPGPPPPASP PGAPASPRAP RTSPYGGLPA APLAGPALPA RRLSRASRPL SASQPSLPHG APGPAASTRP ASSSTPRLGP TPAARAAAPS PDRRDSASPG AAGGLDPQDS. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 76%, Rat - 76%, Pig - 87%, Protein Function: Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity) [The Uniprot Consortium]