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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ABS-PQ-483.20 | 20 µg | - | - | - |
Request delivery time estimate |
270.00€
|
|
| ABS-PQ-483.100 | 100 µg | - | - | - |
Request delivery time estimate |
540.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or... more
Product information "Recombinant Human GNA12 protein"
Protein function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). [The UniProt Consortium]
| Keywords: | Guanine nucleotide-binding protein subunit alpha-12, G alpha-12, G-protein subunit alpha-12, Recombinant Human GNA12 protein |
| Supplier: | Absea |
| Supplier-Nr: | PQ-483 |
Properties
| Conjugate: | No |
| Host: | human cells |
| Species reactivity: | human |
| MW: | 60.5 kD |
| Format: | Solution |
Database Information
| KEGG ID : | K04346 | Matching products |
| UniProt ID : | Q03113 | Matching products |
| Gene ID : | GeneID 2768 | Matching products |
Handling & Safety
| Storage: | -20°C (avoid repeat freezing and thawing cycles) |
| Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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