Recombinant Human GAR1 Protein

Tag: C-His. Modification: unmodified. Start Site: Gly61. End Site: Arg160. Coverage: 0.5. Isoelectric Point: 7.5. Core Sequence: GQDQGPPERV VLLGEFLHPC EDDIVCKCTT DENKVPYFNA PVYLENKEQI GKVDEIFGQL RDFYFSVKLS ENMKASSFKK LQKFYIDPYK LLPLQRFLPR. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 96%, Rat - 97%, Pig - 99%, Cynomolgus monkey - 100%, Protein Function: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme [The Uniprot Consortium]