Recombinant Human FZD5 Protein

Tag: C-His. Modification: unmodified. Start Site: Arg161. End Site: Asp230. Coverage: 0.15. Isoelectric Point: 8.5. Core Sequence: RPFPAKPTLP GPPGAPASGG ECPAGGPFVC KCREPFVPIL KESHPLYNKV RTGQVPNCAV PCYQPSFSAD. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 91%, Rat - 91%, Pig - 93%, Protein Function: Receptor for Wnt proteins (PubMed:10097073, PubMed:20530549, PubMed:26908622, PubMed:9054360). Functions in the canonical Wnt/beta-catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (By similarity). In neurons, activation by WNT7A promotes formation of synapses (PubMed:20530549). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). Plays a role in ocular development (PubMed:26908622) [The Uniprot Consortium]