Recombinant Human FGD5 Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Leu901. End Site: Ser1100. Coverage: 0.14. Isoelectric Point: 5. Core Sequence: LSSEKAYVEM LQHLNLDFHG AVMRALDDMD HEGRDTLARE ELRQGLSELP AIHDLHQGIL EELEERLSNW ESQQKVADVF LAREQGFDHH ATHILQFDRY LGLLSENCLH SPRLAAAVRE FEQSVQGGSQ TAKHRLLRVV QRLFQYQVLL TDYLNNLCPD SAEYDNTQGA LSLISKVTDR ANDSMEQGEN LQKLVHIEHS. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 81%, Rat - 28%, Pig - 87%, Cynomolgus monkey - 99%, Protein Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape [The Uniprot Consortium]