Recombinant Human CORIN Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Ser581. End Site: Lys780. Coverage: 0.2. Isoelectric Point: 4.5. Core Sequence: SPSHFKCRSG QCVLASRRCD GQADCDDDSD EENCGCKERD LWECPSNKQC LKHTVICDGF PDCPDYMDEK NCSFCQDDEL ECANHACVSR DLWCDGEADC SDSSDEWDCV TLSINVNSSS FLMVHRAATE HHVCADGWQE ILSQLACKQM GLGEPSVTKL IQEQEKEPRW LTLHSNWESL NGTTLHELLV NGQSCESRSK. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 82%, Rat - 82%, Pig - 88%, Cynomolgus monkey - 97%, Protein Function: Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity) , Has weaker endopeptidase activity compared to isoform 1 [The Uniprot Consortium]