Recombinant Human CCKBR Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Phe251. End Site: Pro320. Coverage: 0.16. Isoelectric Point: 5.5. Core Sequence: FDGDSDSDSQ SRVRNQGGLP GAVHQNGRCR PETGAVGEDS DGCYVQLPRS RPALELTALT APGPGSGSRP. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 73%, Rat - 69%, Pig - 75%, Cynomolgus monkey - 89%, Protein Function: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system , Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism [The Uniprot Consortium]