Recombinant Human CCDC115 Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Leu31. End Site: Val130. Coverage: 0.59. Isoelectric Point: 6. Core Sequence: LNARVEEGWL SLAKARYAMG AKSVGPLQYA SHMEPQVCLH ASEAQEGLQK FKVVRAGVHA PEEVGPREAG LRRRKGPTKT PEPESSEAPQ DPLNWFGILV. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 78%, Pig - 82%, Cynomolgus monkey - 93%, Protein Function: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833332) [The Uniprot Consortium]