Recombinant Human BNIP1 Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Ile11. End Site: Leu120. Coverage: 0.55. Isoelectric Point: 6. Core Sequence: ICNQEIVKFD LEVKALIQDI RDCSGPLSAL TELNTKVKEK FQQLRHRIQD LEQLAKEQDK ESEKQLLLQE VENHKKQMLS NQASWRKANL TCKIAIDNLE KAELLQGGDL. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 93%, Rat - 94%, Pig - 96%, Cynomolgus monkey - 99%, Protein Function: As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311). Also plays a role in apoptosis (PubMed:15272311, PubMed:23896122, PubMed:7954800). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable) [The Uniprot Consortium]