Recombinant Human APLP2 Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Gln51. End Site: Tyr200. Coverage: 0.22. Isoelectric Point: 5.5. Core Sequence: QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ FFHKERMEVC ENHQHWHTVV KEACLTQGMT LYSYGMLLPC GVDQFHGTEY. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 89%, Rat - 91%, Pig - 95%, Cynomolgus monkey - 98%, Protein Function: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) [The Uniprot Consortium]