Recombinant Human ACSS1 Protein

Tag: C-His. Modification: unmodified. Start Site: Gly561. End Site: Lys680. Coverage: 0.2. Isoelectric Point: 7.5. Core Sequence: GTAEIEDAIA DHPAVPESAV IGYPHDIKGE AAFAFIVVKD SAGDSDVVVQ ELKSMVATKI AKYAVPDEIL VVKRLPKTRS GKVMRRLLRK IITSEAQELG DTTTLEDPSI IAEILSVYQK. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 80%, Rat - 43%, Pig - 83%, Cynomolgus monkey - 99%, Protein Function: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity) [The Uniprot Consortium]