PTPN13_1 PDZ Domain

The protein is provided in 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2 and 25% (v/v) glycerol, at a 0.5 mg/mL concentration.Sequence: SSPEREITLV NLKKDAKYGL GFQIIGGEKM GRLDLGIFIS SVAPGGPADL DGCLKPGDRL ISVNSVSLEG VSHHAAIEIL QNAPEDVTLV ISQPKEKISK VPST. Components: PTPN13_1 PDZ Domain. Shipping Conditions: Room Temperature. Storage Conditions: -30°C to -15°C. Application: Drug Discovery. Optimal pH: 7. Optimal Temperature: 36.5 °C. Features: Optimum temperature: 36.5 °C, pH: 7.0, Protein concentration: 0.5 mg/mL, Recombinant protein purified from Escherichia coli. Product Category: PDZ Domains. Molecular Weight: 13,91 KDa. Protein function: Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). [The UniProt Consortium]