Protein IL-40 (C17orf99), human, recombinant

Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 21-265aa. Protein Length: Full Length of Mature Protein. Tag Info: C-terminal hFc-tagged. Target Protein Sequence: REEEITPVVS IAYKVLEVFP KGRWVLITCC APQPPPPITY SLCGTKNIKV AKKVVKTHEP ASFNLNVTLK SSPDLLTYFC WASSTSGAHV DSARLQMHWE LWSKPVSELR ANFTLQDRGA GPRVEMICQA SSGSPPITNS LIGKDGQVHL QQRPCHRQPA NFSFLPSQTS DWFWCQAANN ANVQHSALTV VPPGGDQKME DWQGPLESPI LALPLYRSTR RLSEEEFGGF RIGNGEVRGR KAAAM. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses. Involved in lymphocyte B cell development and immunoglobulin/IgA production. Reference: "Identification of IL-40, a novel B cell-associated cytokine." Catalan-Dibene J., Vazquez M.I., Luu V.P., Nuccio S.P., Karimzadeh A., Kastenschmidt J.M., Villalta S.A., Ushach I., Pone E.J., Casali P., Raffatellu M., Burkhardt A.M., Hernandez-Ruiz M., Heller G., Hevezi P.A., Zlotnik A. J. Immunol. 199:3326-3335(2017). Function: nan