Prolow-density lipoprotein receptor-related protein 1 (LRP1), partial, human, recombinant

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 2522-2941aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: SSCRAQDEFE CANGECINFS LTCDGVPHCK DKSDEKPSYC NSRRCKKTFR QCSNGRCVSN MLWCNGADDC GDGSDEIPCN KTACGVGEFR CRDGTCIGNS SRCNQFVDCE DASDEMNCSA TDCSSYFRLG VKGVLFQPCE RTSLCYAPSW VCDGANDCGD YSDERDCPGV KRPRCPLNYF ACPSGRCIPM SWTCDKEDDC EHGEDETHCN KFCSEAQFEC QNHRCISKQW LCDGSDDCGD GSDEAAHCEG KTCGPSSFSC PGTHVCVPER WLCDGDKDCA DGADESIAAG CLYNSTCDDR EFMCQNRQCI PKHFVCDHDR DCADGSDESP ECEYPTCGPS EFRCANGRCL SSRQWECDGE NDCHDQSDEA PKNPHCTSQE HKCNASSQFL CSSGRCVAEA LLCNGQDDCG DSSDERGCHI. Purity: Greater than 95% as determined by SDS-PAGE. Endotoxin: n/a. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. , (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. Reference: n/a. Function: nan