Prion-Like Protein Doppel/PRND Protein(C-6His) (recombinant human)

Protein Construction: Recombinant Human Prion-like protein doppel is produced by our Mammalian expression system and the target gene encoding Arg27-Gly152 is expressed with a 6His tag at the C-terminus. Sequence: Arg27-Gly152. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 20-29 kDa. Protein function: Prion-like protein doppel is a 152 amino acids protein that belongs to the prion family. The protein encoded by this gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. It is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. Protein function: Required for normal acrosome reaction and for normal male fertility. Can bind Cu(2+) (PubMed:15218028, PubMed:20411530). [The UniProt Consortium]