PLpro (SARS Coronavirus) (rec.) (His)

PLpro (SARS Coronavirus) (rec.) (His)
COVID-19 Research
Item number Size Datasheet Manual SDS Delivery time Quantity Price
SBB-DE0024-C050 50 µg - -

3 - 9 business days*

222.00€
 
The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is... more
Product information "PLpro (SARS Coronavirus) (rec.) (His)"
The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is involved in the processing of the viral polyprotein. Proteolytic processing of the coronavirus replicase poly-protein is essential for generating a functional virus replication complex. PLpro possesses both deubiquitinating or deISGylating activity and can process Lys48 and Lys63 linked polyubiquitin chains (free chains or from cellular substrates). It works in concert together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. It strongly antagonizes the innate immune induction of type I interferon by blocking the phosphorylation, dimerization and therefore the nuclear translocation of host IRF3. In addition, it prevents also host NF-kappa-B signaling.
Keywords: Papain-like Proteinase, SARS Coronavirus Main Proteinase, Non-structural Protein 3, PL2-PRO, Nsp3
Supplier: South Bay Bio
Supplier-Nr: DE0024

Properties

Application: Assays
Conjugate: No
Expressed in: E.coli
Origin: Sars-cov
MW: 37 kD
Purity: >95%
Format: Liquid

Database Information

UniProt ID : P0C6U8 | Find alternatives
Gene ID GeneID 1489680 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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