Platelet Derived Growth Factor B (PDGF-B)

Protein Length: Ser82-Thr190. Protein Tag: N terminal containing a HIS tag. The term 'PDGF' refers to a family of disulphide bondlinked dimeric isoforms that act as autocrine and paracrine growth factors and are produced by a variety of cell types other than platelets. They act as potent mitogens for almost all mesenchymally-derived cells. Aberrant expression is involved in certain cancers, fibroproliferative disorders and atherosclerosis. The protein also contributes to wound healing and neural regeneration. There are four members of the PDGF family - PDGF A, PDGF B, PDGF C and PDGF D. RANDOX recombinant PDGF-B comprises a 109 amino acid fragment (82-190) corresponding to the mature PDGF-B chain protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use