PDZD8 PDZ Domain

The protein is provided in 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2 and 25% (v/v) glycerol, at a 0.5 mg/mL concentration.Sequence: KQRSSIKTVE LIKGNLQSVG LTLRLVQSTD GYAGHVIIET VAPNSPAAIA DLQRGDRLIA IGGVKITSTL QVLKLIKQAG DRVLVYYERP VGQSNQGAVL QDN. Components: PDZD8 PDZ Domain. Shipping Conditions: Room Temperature. Storage Conditions: -30°C to -15°C. Application: Drug Discovery. Optimal pH: 7. Optimal Temperature: 36.5 °C. Features: Optimum temperature: 36.5 °C, pH: 7.0, Protein concentration: 0.5 mg/mL, Recombinant protein purified from Escherichia coli. Product Category: PDZ Domains. Molecular Weight: 13,98 KDa. Protein function: Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). [The UniProt Consortium]