PD-L1, Recombinant, Mouse, aa18-238, Fc-Tag, (PE)

Programmed death-ligand 1 (PD-L1), also known as CD274 or B7-H1, is a protein that in humans is encoded by the CD274 gene. It is mapped to 9p24.1. PD-L1 is a 40kD type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. It has been concluded that upregulation of PD-L1 on tumor MDCs downregulates T-cell immunity and that PD-L1 blockade may represent an approach for cancer immunotherapy. Additionally, PD-L1 can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection. PD-L1 has been found that PD1/PDL1 pathway may be a good target for restoring antitumor immunity in ovarian cancer. Recombinant protein corresponding to aa18-238 from mouse PD-L1, fused at the C-terminus to the Fc portion of mouse IgG2a, expressed in a HEK293 cells. The protein was randomly labeled with RPE on accessible lysine residues. , Molecular Weight:, ~51kD, Applications: Suitable for the use in study of labeling PD-1 expressing cells for flow cytometry or immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.