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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay30591-50 | 50 µg | - |
6 - 10 business days* |
716.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Proprotein convertase subtilisin kexin 9 (PCSK9) is a zymogen and member of the subtilisin serine... more
Product information "PCSK9-DyLight(TM) 488"
Proprotein convertase subtilisin kexin 9 (PCSK9) is a zymogen and member of the subtilisin serine protease family that reduces protein levels of LDL receptors (LDLRs), the receptor for LDL-cholesterol (LDL-C). It is primarily expressed in the liver and is composed of an N-terminal prodomain that regulates PCSK9 maturation, a catalytic domain containing a catalytic aspartic acid-histidine-serine triad, and a C-terminal domain that contains the LDLR binding site. PCSK9 is synthesized as a proprotein that is autocatalytically cleaved to generate the 63 kDa mature protein in which the N-terminal prodomain remains non-covalently bound to the catalytic domain to inhibit further activity. The mature PCSK9 is secreted and circulates in the plasma where it binds to cell surface-expressed LDLRs, triggering endocytosis and lysosomal degradation of the PCSK9-LDLR complex. This action decreases LDLR expression and reduces cellular LDL-C uptake. Gain-of-function and loss-of-function PCSK9 mutations have been associated with autosomal dominant hypercholesterolemia and decreased plasma LDL-C levels, respectively, in humans. Reducing the activity of circulating PCSK9 with monoclonal antibodies or small molecule inhibitors decreases LDL-C levels and reduces the risk of adverse cardiovascular events in individuals with hypercholesterolemia. Cayman's PCSK9-DyLight(TM) 488 is synthesized as a 75.8 kDa proprotein. After cleavage of the signal peptide (1-30 AA) PCKS9 autocatalytically cleaves to the 13.8 kDa prodomain (AA 31-152) and the 59 kDa mature form (AA 153-692 + 10x His-tag) and can be used for cell-based assays.Synonyms: NARC-1, Proprotein Convertase Subtilisin Kexin 9. Purity: >90% estimated by SDS-PAGE. Source: Active recombinant C-terminal His-tagged enzyme expressed in HEK293 cells. Conjugated to DyLight(TM) 488. Amino Acids: 1-692 (full length). MW: 13.8 kDa prodomain + 59 kDa mature form. Formulation: (Request formulation change), Lyophilized from PBS, pH 7.4, with 30% sucrose. UniProt Accession #: Q8NBP7.
Keywords: | PC9, PC9, PCSK9, NARC1, NARC-1, NARC-1, PSEC0052, Proprotein convertase 9, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, Neural apoptosis-regulated convertase 1, P |
Supplier: | Cayman Chemical |
Supplier-Nr: | 30591 |
Properties
Application: | Active enzyme |
Conjugate: | DyLight 488 |
Purity: | >90% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K13050 | Matching products |
UniProt ID : | Q8NBP7 | Matching products |
Gene ID | GeneID 255738 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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