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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ABS-PP-6437-L.20 | 20 µg | - | - | - |
10 - 15 business days* |
115.00€
|
|
| ABS-PP-6437-L.100 | 100 µg | - | - | - |
10 - 15 business days* |
205.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate... more
Product information "PARP14 (human), recombinant protein"
Protein function: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:27796300, PubMed:18851833, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP- ribosylates STAT6, enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300). [The UniProt Consortium]
| Keywords: | Protein mono-ADP-ribosyltransferase PARP14, ADP-ribosyltransferase diphtheria toxin-like 8, ARTD8, B aggressive lymphoma protein 2, Poly [ADP-ribose] polymerase 14, PARP-14, Recombinant Human PARP14 Protein |
| Supplier: | Absea |
| Supplier-Nr: | PP-6437-L |
Properties
| Conjugate: | No |
| Host: | E.coli |
| Species reactivity: | human |
| MW: | 33.5 kD |
| Format: | Lyophilized |
Database Information
| KEGG ID : | K15261 | Matching products |
| UniProt ID : | Q460N5 | Matching products |
| Gene ID : | GeneID 54625 | Matching products |
Handling & Safety
| Storage: | -20°C (protect from light & moisture) |
| Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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