Osteomodulin (human, recombinant)

Osteomodulin (OMD), is a class II keratan sulfate small leucine-rich proteoglycan (SLRP) with roles in bone mineralization, cell adhesion, tooth formation, and the regulation of collagen fibrils. It is primarily expressed in mineralized tissues, including bones and teeth, but is also expressed in articular chondrocytes and fibrochondrocytes. OMD binds to bone morphogenetic protein 2 (BMP2), promoting SMAD signaling and osteogenesis. It also binds to type I collagen and induces morphology and size changes in collagen fibrils, indicating a role in the regulation of extracellular matrix components during bone formation. Increased plasma levels of OMD are associated with cardiac calcification in patients with chronic kidney disease (CKD). Serum levels of OMD are increased and positively correlated with plaque calcification in patients with carotid atherosclerosis. Serum levels of OMD are also decreased in patients with osteoarthritis. Cayman's Osteomodulin (human, recombinant) protein consists of 412 amino acids, has a calculated molecular weight of 48.6 kDa, and a predicted N-terminus of Gln21 after signal peptide cleavage.Synonyms: Keratan Sulfate Proteoglycan Osteomodulin, KSPG Osteomodulin, OMD, OSAD, Osteoadherin. Purity: >95% as determined by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg, determined by the LAL endotoxin assay. Source: Recombinant human C-terminal His-tagged osteomodulin expressed in HEK293 cells. Amino Acids: 21-421. MW: 48.6 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. UniProt Accession #: Q99983.