OCRL (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-5778-L.20	20 µg		-	-	Request delivery time estimate		115.00€
ABS-PP-5778-L.100	100 µg		-	-	Request delivery time estimate		205.00€

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Protein function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol... more

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Product information "OCRL (human), recombinant protein"

Protein function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:7761412, PubMed:15474001, PubMed:9430698, PubMed:10764818). Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:7761412, PubMed:25869668). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788). [The UniProt Consortium]

Keywords:	Inositol polyphosphate 5-phosphatase OCRL, Inositol polyphosphate 5-phosphatase OCRL-1, OCRL-1, Lowe oculocerebrorenal syndrome protein, Phosphatidylinositol 3, 4, 5-triphosphate 5-phosphatase, Recombinant Human OCRL Protein
Supplier:	Absea
Supplier-Nr:	PP-5778-L

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	26 kD
Format:	Lyophilized

Database Information

KEGG ID :	K01099 \| Matching products
UniProt ID :	Q01968 \| Matching products
Gene ID :	GeneID 4952 \| Matching products

Handling & Safety

Storage:	-20°C (protect from light & moisture)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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