Nucleocapsid Protein (recombinant sars-cov)

Activity: Test in progress Protein Construction: Recombinant SARS-CoV Nucleocapsid Protein is produced by our E.coli expression system and the target gene encoding Met1-Ala422 is expressed with a 6His tag at the N-terminus. Sequence: Met1-Ala422. Fusion tag: N-6His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 58kDa. Protein function: Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. N protein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool. Protein function: Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455). [The UniProt Consortium]