NR4A3 Ligand-binding Domain (human, recombinant)

Nuclear receptor subfamily 4 group A member 3 (NR4A3) is a transcription factor and member of the NR4A orphan nuclear receptor family. It is composed of an N-terminal activation function-1 (AF-1) transactivation domain, a DNA-binding domain, a variable linker region, and a C-terminal domain comprising a ligand-binding domain and an AF-2 domain. NR4A3 is primarily expressed in the fetal brain and lungs and adult heart and skeletal muscle, with both splice variants showing similar expression patterns. It is involved in several biological processes, including apoptosis, differentiation, metabolism, inflammation, cardiac remodeling, and development, and its expression can be induced by several factors such as growth factors, cytokines, and stress. Knockout of Nr4a3 inhibits GM-CSF- and IL-4-induced differentiation of primary mouse monocytes into dendritic cells. Overexpression of NR4A3 reduces infarct size as a percentage of the area at risk in a mouse model of acute myocardial infarction. Fusion proteins of NR4A3 with Ewing sarcoma protein (EWS) or TAF15 are associated with extraskeletal myxoid chondrosarcoma.Synonyms: Mitogen-induced Nuclear Orphan Receptor, Neuron-derived Orphan Receptor 1, Nuclear Hormone Receptor NOR-1, Nuclear Receptor Subfamily 4 Group A Member 3. Purity: >80%. Source: Recombinant human N-terminal His-tagged NR4A3 expressed in E. coli. Amino Acids: 398-626. MW: 27.74 kDa. Formulation: (Request formulation change), 50 mM Tris HCl, pH 7.5, with 100 mM sodium chloride, and 2% glycerol. UniProt Accession No: Q92570.