Notch 2[Biotin], His & Avi, Human

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
GSC-Z04573-100	100 µg		-		Request delivery time estimate		887.00€
GSC-Z04573-500	500 µg		-		Request delivery time estimate		2,943.00€

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Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch... more

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Product information "Notch 2[Biotin], His & Avi, Human"

Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch-2 is lethal, showing that not all functions overlap.Notch-2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

Keywords:	NOTCH2, Neurogenic locus notch homolog protein 2
Supplier:	GenScript
Supplier-Nr:	Z04573

Properties

Conjugate:	Biotin
Species reactivity:	human
MW:	57 kD
Purity:	>95% (Bis-Tris PAGE)

Database Information

KEGG ID :	K20994 \| Matching products
UniProt ID :	Q04721 \| Matching products
Gene ID :	GeneID 4853 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: °C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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