Nanog, Recombinant, Human, aa1-305 (Early Embryo Specific Expression NK Family Gene, Embryonic Stem

Nanog, Recombinant, Human, aa1-305 (Early Embryo Specific Expression NK Family Gene, Embryonic Stem
Item number Size Datasheet Manual SDS Delivery time Quantity Price
N0019-01Z.100 100 µg - -

4 - 22 business days

451.00€
 
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation... more
Product information "Nanog, Recombinant, Human, aa1-305 (Early Embryo Specific Expression NK Family Gene, Embryonic Stem"
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation (By similarity). [The UniProt Consortium]
Keywords: hNanog, Homeobox protein NANOG, Homeobox transcription factor Nanog
Supplier-Nr: N0019-01Z

Properties

MW: 34,6 kD
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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