N-Sulphoglucosamine Sulphohydrolase/SGSH Protein(C-6His) (recombinant human)

Protein Construction: Recombinant Human N-Sulphoglucosamine Sulphohydrolase is produced by our Mammalian expression system and the target gene encoding Arg21-Leu502 is expressed with a 6His tag at the C-terminus. Sequence: Arg21-Leu502. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 63 kDa. Protein function: N-Sulphoglucosamine Sulphohydrolase (SGSH) is an important member of the sulfatase family which is involved in the degradation of heparin sulfate. SGSH binds one calcium ion per subunit as a cofactor. SGSH catalyzes N-sulfo-D-glucosamine and H2O to D-glucosamine and sulfate. SGSH deficiency is result in mucopolysaccharidosis type 3A (MPS3A), a recessive lysosomal storage disease characterized by neurological dysfunction but relatively mild somatic manifestations. Protein function: Catalyzes a step in lysosomal heparan sulfate degradation. [The UniProt Consortium]