Mouse Frizzled-10, recombinant (VLP)

Recombinant Mouse Frizzled-10 is produced by our Mammalian expression system and the target gene encoding Ile22-Val582 is expressed with a Flag tag at C-terminus. VLPs are self-assembled from viral envelope/capsid protein and can display conformationally intact membrane protein in natural cell membranes. Protein function: Receptor for Wnt proteins (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). [The UniProt Consortium]