Mouse DDR2, recombinant (C-6His)

Recombinant Mouse Discoidin Domain-containing Receptor 2 is produced by our Mammalian expression system and the target gene encoding Gln24-Arg399 is expressed with a 6His tag at the C-terminus. Protein function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up- regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. [The UniProt Consortium]