Mouse CXADR, recombinant (C-Fc)

Recombinant Mouse Coxsackievirus And Adenovirus Receptor Homolog is produced by our Mammalian expression system and the target gene encoding Leu20-Gly237 is expressed with a human IgG1 Fc tag at the C-terminus. Protein function: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3- kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. [The UniProt Consortium]