METTL1 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-3323-L.20	20 µg	-	-	-	Request delivery time estimate		115.00€
ABS-PP-3323-L.100	100 µg	-	-	-	Request delivery time estimate		205.00€

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Protein function: Methyltransferase that mediates the formation of N(7)- methylguanine in a... more

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Product information "METTL1 (human), recombinant protein"

Protein function: Methyltransferase that mediates the formation of N(7)- methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:31031084). Internal N(7)-methylguanine methylation of mRNAs regulates translation (PubMed:31031084). Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083). Acts as a regulator of embryonic stem cell self-renewal and differentiation. [The UniProt Consortium]

Keywords:	tRNA, guanine-N(7)-)-methyltransferase, Methyltransferase-like protein 1, mRNA, guanine-N(7)-)-methyltransferase, miRNA, guanine-N(7)-)-methyltransferase, tRNA, guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase, Recombinant Human METTL1 P
Supplier:	Absea
Supplier-Nr:	PP-3323-L

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	25.5 kD
Format:	Lyophilized

Database Information

KEGG ID :	K03439 \| Matching products
UniProt ID :	Q9UBP6 \| Matching products
Gene ID :	GeneID 4234 \| Matching products

Handling & Safety

Storage:	-20°C (protect from light & moisture)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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