MBNL2 PrEST Antigen

MBNL2 PrEST Antigen
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ATA-APrEST89996.100 100 µl - -

7 - 10 business days*

264.00€
 
Protein function: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or... more
Product information "MBNL2 PrEST Antigen"
Protein function: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). [The UniProt Consortium] Buffer: PBS and 1M Urea, pH 7.4.
Keywords: MBLL, MBNL2, Muscleblind-like protein 1, Muscleblind-like protein 2, Muscleblind-like protein-like, Muscleblind-like protein-like 39
Supplier: Atlas Antibodies
Supplier-Nr: APrEST89996

Properties

Application: Control antigen
Conjugate: No
Host: E.coli
Species reactivity: human

Handling & Safety

Storage: -20°C (avoid repeat freezing and thawing cycles)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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