Macaque Tumor-associated Calcium Signal Transducer 2/TROP-2 (C-6His) (recombinant rhesus)

Activity: Immobilized Rhesus Macaque TROP-2-His(Cat#PKSQ050121) at 2µg/ml (100 µl/well) can bind Anti-Human TROP-2 mAb .The ED50 of Anti-Human TROP-2 mAb is 4.7 ng/ml. Protein Construction: Recombinant Rhesus Macaque Tumor-associated Calcium Signal Transducer 2 is produced by our Mammalian expression system and the target gene encoding His27-Arg272 is expressed with a 6His tag at the C-terminus. Sequence: His27-Arg272. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 38-45 kDa. Protein function: Tumor associated calcium signal transducer 2 (TACSTD2, TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. Human and mouse TROP-2 share 87% amino acid (aa) similarity. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions. Protein function: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). [The UniProt Consortium]