Macaque Angiotensin-Converting Enzyme 2/ACE-2 (C-Fc) (recombinant rhesus)

Activity: Immobilized 2019-nCoV S Protein RBD-SD1-mFc(Cat#PKSR030476)at 2µg/ml (100 µl/well) can bind Rhesus Macaque ACE-2-Fc(Cat#PKSQ050120).The ED50 of Recombinant Rhesus Macaque ACE-2-His(Cat#PKSQ050120)is 96 ng/ml. Protein Construction: Recombinant Rhesus Macaque Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Val739 is expressed with a Fc tag at the C-terminus. Sequence: Gln18-Val739. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 120-140 kDa. Protein function: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don't inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.