LTbetaR (mouse):Fc (human) (rec.) MultiPack

Lymphotoxin beta receptor (LTbetaR) belongs to the tumor necrosis factor receptor superfamily (TNFR) and is a key regulator of lymphoid organogenesis and inflammation. LTbetaR is primarily expressed by epithelial cells, dendritic cells (DCs), stromal cells and macrophages. LTbetaR interacts with two ligands: membrane heterotrimeric lymphotoxin LTalpha1beta2 (LT) and homotrimeric LIGHT, both expressed predominantly by activated lymphoid cells. LTbetaR signaling can activate both canonical and alternative NF-kB signaling to induce various proinflammatory chemokines and cytokines and promote apoptosis via TRAF3 and TRAF5. LTbetaR also plays a role in the development of lymphoid organs. LTbetaR (mouse):Fc treatment partially impairs the structure of secondary lymphoid organs and shows therapeutic efficacy in various models of inflammatory diseases.