KANK2 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-7820-L.20	20 µg	-	-	-	Request delivery time estimate		115.00€
ABS-PP-7820-L.100	100 µg	-	-	-	Request delivery time estimate		205.00€

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Protein function: Involved in transcription regulation by sequestering in the cytoplasm nuclear... more

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Product information "KANK2 (human), recombinant protein"

Protein function: Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation. [The UniProt Consortium]

Keywords:	KN motif and ankyrin repeat domain-containing protein 2, Ankyrin repeat domain-containing protein 25, Matrix-remodeling-associated protein 3, SRC-1-interacting protein, SIP, SRC-interacting protein, SRC1-interacting protein, Recombinant Human KANK2 Protei
Supplier:	Absea
Supplier-Nr:	PP-7820-L

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	28.5 kD
Format:	Lyophilized

Database Information

KEGG ID :	K22808 \| Matching products
UniProt ID :	Q63ZY3 \| Matching products
Gene ID :	GeneID 25959 \| Matching products

Handling & Safety

Storage:	-20°C (protect from light & moisture)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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