IL-1 Receptor-Like 2/IL-1RL2/IL-1Rrp2/IL-36R (C-Fc) (recombinant mouse)

Protein Construction: Recombinant Mouse Interleukin-1 Receptor-like 2 is produced by our Mammalian expression system and the target gene encoding Asp22-Arg338(Ala158Val) is expressed with a Fc tag at the C-terminus. Sequence: Asp22-Arg338(Ala158Val). Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 85-120 kDa. Protein function: Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene, belongs to the interleukin-1 receptor family.IL1RL2 is the receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. Protein function: Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36- dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response, it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. [The UniProt Consortium]