IGF2BP2 Long Isoform (human, recombinant)

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is an RNA-binding protein (RBP) and a member of the zipcode-binding protein (ZBP) family. It is composed of two N-terminal RNA recognition motifs (RRMs) and four C-terminal heterogeneous nuclear ribonucleoprotein (hnRNP) K-homology (KH) domains. IGF2BP2 is ubiquitously expressed during development and localizes to the cytoplasm. It exists as three isoforms: p58, which lacks an RRM motif, p62, which has a shortened linker region between KH2 and KH3, and the full-length isoform, p66. IGF2BP2 is involved in RNA processing through N6-methyladenosine (m6A) recognition, metabolism, neurogenesis, and embryonic development and interacts with several target transcripts, including IGF2, LAMB2, TRIM54, EIF4A1, and NTN4, as well as some mitochondrial genes. IGF2BP2 promotes or inhibits invasion and migration of cancer cells in vitro in a context-dependent manner. SNPs in IGF2BP2 are associated with an increased risk of type 2 diabetes. Cayman's IGF2BP2 long isoform (human, recombinant) protein consists of 836 amino acids and has a calculated molecular weight of 94 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular weight of the protein is 90 kDa.Synonyms: IGF2 mRNA-binding Protein 2, Insulin-like Growth Factor 2 mRNA-binding Protein 2, IMP-2, VICKZ2. Purity: >76% as estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg determined by the LAL endotoxin assay. Source: Recombinant human N-terminal His-and GST-tagged IGF2BP2 long isoform expressed in insect cells. Amino Acids: 1-599. MW: 94 kDa. Formulation: (Request formulation change), Lyophilized from sterile 50 mM Tris, pH 8.0, 500 mM sodium chloride, 0.5 mM PMSF, and 5 mM reduced glutathione. UniProt Accession No: Q9Y6M1.