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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
044896.50 | 50 µg | - | - |
3 - 19 business days* |
656.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan... more
Product information "IDO, Recombinant, Mouse (His) (Indoleamine 2,3-dioxygenase, INDO)"
IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders. Recombinant protein corresponding to mouse IDO (aa1-407), at C-terminus fused to His-tag. , Biological Activity:, Specific Activity: >100,000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour. Heme Content: Not determined for end product. 7uM hemin was adde for protein induction. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Ido, Ido1, IDO-1, EC=1.13.11.52, Indoleamine 2,3-dioxygenase 1, Indoleamine-pyrrole 2,3-dioxygenase |
Supplier: | United States Biological |
Supplier-Nr: | 044896 |
Properties
Conjugate: | No |
Species reactivity: | mouse |
Format: | Highly Purified |
Database Information
KEGG ID : | K00463 | Matching products |
UniProt ID : | P28776 | Matching products |
Gene ID | GeneID 15930 | Matching products |
Handling & Safety
Storage: | vT |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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