Human Transthyretin/Prealbumin Protein

Recombinant Human Transthyretin/Prealbumin Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly21-Glu147. Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known, however, many other functions have emerged, namely in the nervous system. TTR aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. Normal TTR can also aggregate and deposit in the heart of old people and in preeclampsia placental tissue.