Human PVR, recombinant (C-mFc)

Recombinant Human Poliovirus Receptor is produced by our Mammalian expression system and the target gene encoding Trp21-Asn343 is expressed with a mouse IgG1 Fc tag at the C-terminus. Protein function: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. [The UniProt Consortium]