Human P2RX6-Strep full length protein-synthetic nanodisc

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]. Human P2RX6-Strep full length protein-synthetic nanodisc. Protein function: Receptor for ATP that acts as a ligand-gated ion channel. [The UniProt Consortium]