Human MAP1LC3A, recombinant (C-6His)

Recombinant Human Microtubule-Associated Protein 1 Light Chain 3 Alpha is produced by our E.coli expression system and the target gene encoding Met1-Phe121 is expressed with a 6His tag at the C-terminus. Protein function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). [The UniProt Consortium]