Human LRP-5 Protein

Recombinant Human LRP-5 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu644-Gln1263. A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis.