Human KCTD6-Strep full length protein-synthetic nanodisc

Item number	Size	Manual	SDS	Delivery time	Price
DIM-FLP120716.10	10 µg	-	-	7 - 16 business days*	1,185.00€
DIM-FLP120716.50	50 µg	-	-	7 - 16 business days*	5,793.00€
DIM-FLP120716.100	100 µg	-	-	7 - 16 business days*	10,534.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex... more

Close menu

Product information "Human KCTD6-Strep full length protein-synthetic nanodisc"

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1, the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1, the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).[UniProtKB/Swiss-Prot Function]. Human KCTD6-Strep full length protein-synthetic nanodisc. Protein function: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1, the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1, the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887). [The UniProt Consortium]

Keywords:	KCTD6, KCASH3 protein, BTB/POZ domain-containing protein KCTD6, Potassium channel tetramerization domain-containing protein 6
Supplier:	DIMA
Supplier-Nr:	FLP120716

Properties

Application:	Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization
Conjugate:	No
Host:	Human cells
Species reactivity:	human
MW:	27.6 kD
Format:	Lyophilized

Database Information

KEGG ID :	K21916 \| Matching products
UniProt ID :	Q8NC69 \| Matching products
Gene ID :	GeneID 200845 \| Matching products

Handling & Safety

Storage:	-20°C (avoid repeat freezing and thawing cycles)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

Information about the product reference will follow. more

Close menu

You will get a certificate here

Go back

Read, write and discuss reviews... more

Close menu

Customer review for "Human KCTD6-Strep full length protein-synthetic nanodisc"

Write a review