Human HLA-A*0201 GP100 complex Protein (C-Avi-10His), biotinylated

Biotinylated Recombinant Human B2M&HLA-A is produced by our Mammalian expression system and the target gene encoding (IMDQVPFSV)&Ile21-Met119&Gly25-Ile308 (Ala269Val) is expressed with a Avi, 10His tag at the C-terminus. Protein function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). [The UniProt Consortium]